The phytoestrogens in red clover may be expected to act through estrogenic mechanisms, with the associated risk of estrogen-like adverse effects, including increased incidence of endometrial, ovarian, and breast cancers. Some of these nutrients include calcium, chromium, magnesium, niacin, phosphorus, potassium, thiamine, and vitamin C. The substances that have recently put red clover in the spotlight, however, are isoflavones. Because red clover thins the blood, those with blood-clotting abnormalities should probably not take this supplement. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). In case of overdose, get medical help or contact a Poison Control Center immediately. Clinical trials have used higher doses (160 mg/day); however, long-term safety of such doses has not been established.21 Crude plant extract 240 mg approximates to 40 mg of isoflavones.1 Several commercial preparations are available. The appropriate dose of red clover depends on several factors such as the user’s age, health, and several other conditions. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Red clover is a nutrient-dense herb that is best extracted with water. It has a taproot, unlike other clovers that have a creeping root system. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Medscape - Indication-specific dosing for beebread, cow clover, meadow clover, purple clover, trefle des pres, trefoil, trifolium pratense, wild clover (red clover), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. One of the most frequent reasons that people bring their dogs to the vet is for itching, irritated skin. Are there any side effects of using red clover? Two: This is often used for children that have a persistent, bad cough. Scientific Name(s): Trifolium pratense L.Common Name(s): Cow clover, Creeping clover, Flos Trifolii, Meadow clover, Purple clover, Trefoil. Dosage Considerations – Should be Given as Follows: Side effects of bismuth subsalicylate include: This document does not contain all possible side effects and others may occur. Keep out of reach of children. Up to 85 milligrams of isoflavones once daily seems to be safe for … Other constituents include coumaric acid, fats, minerals, and vitamins. Red Clover Extract (Trifolium pratense) Benefits There is a lot of poor quality red clover on the market. With the exception of vaginal dryness, no significant improvement was seen in urogenital subcategory scores; however, mean vegetative somatic scores (eg, hot flushes, heart discomfort, sleeping disorders) and differences in mean psychological scores (eg, anxiety, irritability, physical and mental exhaustion) were significant (P = 0.002, P = 0.0001, respectively). Medically reviewed by Drugs.com. It is naturalized in North America, where its nitrogen-fixing properties are used in pasture renovation. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Dense terminal heads with up to 125 fragrant flowers are borne at the end of the branched stems. Red Clover Uses. Red Clover Preparations and Dosage Red Clover can be ingested in a number of ways. The globular heads of reddish-purple flowers have long been prized by herbalists. Eczema, psoriasis, and rashes all respond to its soothing and healing qualities. Respiratory complaints have been treated with an infusion; fomentations and poultices of the whole plant have been used as topical applications for cancerous growths.3, 4, The main chemical classes contained in red clover are carbohydrates, isoflavones, flavonins, and saponins. More studies are needed. Red clover has no known severe interactions with other drugs. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. Historically, red clover was used for asthma, whooping cough, cancer, and gout. This red clover supplement contains extract from aerial parts of Trifolium pratense. Below are some suggestions. An additive effect may occur if red clover phytoestrogens are taken with hormonal therapies; avoid concurrent use with oral contraceptives, estrogen, or progesterone therapies. Red clover has no known serious interactions with other drugs. Red Clover Extract Supplement. Avoid use. Red clover studies were reviewed that pertained to women's health or menopause. Extracts standardized for isoflavone content have been used frequently in clinical trials.26 These tablets contain biochanin A, formononetin, genistein, and daidzein.7 A usual dosage is 40 to 80 mg/day of total isoflavones (1 to 2 tablets). The flower is a mainstay ingredient in traditional herbal formulas, including Essiac Tea, Jason Winters Tea, and the Hoxsey Therapy. Another study23 evaluated phytoestrogens (not only red clover) by the composite Kupperman Index outcome (7 trials) and by the incidence of hot flushes only (11 trials). With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Red clover blossoms for sedation were formerly used at doses of 4 g, but are now used primarily as a source of isoflavones. The leaves are in groups of 3 ovate leaflets, often notched at the tip, with a characteristic lighter water mark on their upper surface.1, 2, 3, 4, Dried red clover flowers have been used in traditional medicine to treat a wide spectrum of ailments, including jaundice, cancer, mastitis, joint disorders, and respiratory conditions (eg, whooping cough, bronchial asthma), and as a sedative. The flowers range from magenta to white in color and are butterfly shaped. The herb was first utilized in 1917 as a blood purifier and amplified in the 1930s as a supposed anti-tumor remedy, in which its beneficial effects are still in popular use today. Note, the safety of the use of isoflavones, taken as a supplement, cannot be guaranteed when taken for a duration of longer than six months. The isoflavone can be extracted directly from the red clover flower and made into capsules, tablets, liquid extracts, or topical creams depending on your particular symptoms that you want to treat and preferences. See additional information. Moderate interactions of red clover include: Red clover has no known mild interactions with other drugs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Phytoestrogens appear to act as partial agonists in some tissues and antagonists in others, exhibiting hormonal and nonhormonal properties.6 They have a greater affinity for beta-estrogen rather than alpha-estrogen receptors. A Cochrane meta-analysis21 included 7 clinical trials using red clover alone, while 1 study22 evaluated the effect of red clover therapy duration on outcomes and included 8 trials. Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65. 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